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- $Unique_ID{BRK03282}
- $Pretitle{}
- $Title{phenmetrazine}
- $Subject{Preludin Endurets Boehringer Ingelheim Anorectic phenmetrazine
- appetite suppressant dieting nerve impulses appetite control center brain}
- $Volume{}
- $Log{}
-
- Copyright (C) 1993 Publications International, Ltd.
-
-
- phenmetrazine
- ------------------------------------------------------------------------------
-
- BRAND NAME (Manufacturer)
-
- Preludin Endurets (Boehringer Ingelheim)
-
- TYPE OF DRUG
-
- Anorectic
-
- INGREDIENT
-
- phenmetrazine
-
- DOSAGE FORM
-
- Sustained-release tablets (75 mg)
-
- STORAGE
-
- Phenmetrazine should be stored at room temperature in tightly closed,
- light-resistant containers.
-
- USES
-
- Phenmetrazine is used as an appetite suppressant during the first few
- weeks of dieting to help establish new eating habits. This medication is
- thought to relieve hunger by altering nerve impulses to the appetite control
- center in the brain. Its effectiveness lasts only for short periods (three to
- 12 weeks), however.
-
- TREATMENT
-
- You can take phenmetrazine with a full glass of water one hour before
- meals (unless your doctor directs you to do otherwise).
- This medication should be swallowed whole. Breaking, chewing, or
- crushing these tablets destroys their sustained-release activity and may
- increase the side effects.
- To avoid difficulty in falling asleep, take the last dose of this
- medication each day ten to 14 hours before bedtime.
- If you miss a dose of this medication, take the missed dose as soon as
- possible, unless it is almost time for your next dose. In that case, do not
- take the missed dose at all; just return to your regular dosing schedule. Do
- not double the next dose.
-
- SIDE EFFECTS
-
- Minor.
-
- Blurred vision, constipation, diarrhea, dizziness, dry mouth, false sense
- of well-being, fatigue, insomnia, irritability, nausea, nervousness,
- restlessness, stomach pain, sweating, unpleasant taste in the mouth, or
- vomiting. These side effects should disappear as your body adjusts to the
- drug.
- If you experience mouth dryness, try sucking on ice chips or a piece of
- hard candy or chewing sugarless gum.
- In order to prevent constipation, increase the amount of fiber in your
- diet (fresh fruits and vegetables, salads, bran, and whole-grain breads),
- exercise, and drink more water (unless your doctor tells you not to do so).
-
- Major.
-
- Tell your doctor about any side effects that are persistent or
- particularly bothersome. IT IS ESPECIALLY IMPORTANT TO TELL YOUR DOCTOR about
- changes in sexual desire, chest pain, difficulty in urinating, enlarged
- breasts (in both sexes), fever, hair loss, headaches, impotence, menstrual
- irregularities, mental depression, mood changes, mouth sores, muscle pains,
- palpitations, rash, sore throat, tremors, or unusual bleeding or bruising.
-
- INTERACTIONS
-
- Phenmetrazine interacts with several other types of drugs:
- 1. Use of it within 14 days of a monoamine oxidase (MAO) inhibitor
- (isocarboxazid, pargyline, phenelzine, or tranylcypromine can result in high
- blood pressure and other side effects.
- 2. Tricyclic antidepressants and phenothiazine tranquilizers (especially
- chlorpromazine) can antagonize (act against) the appetite-suppressant activity
- of this drug.
- 3. Phenmetrazine can decrease the blood-pressure-lowering effects of
- antihypertensive medications (especially guanethidine) and may alter insulin
- and oral antidiabetic medication dosage requirements in diabetic patients.
- 4. The side effects of other central nervous system stimulants, such as
- caffeine or over-the-counter (nonprescription) diet, cough, cold, sinus,
- asthma, or allergy preparations, may be increased by this medication.
- BE SURE TO TELL YOUR DOCTOR about any medications you are currently
- taking, especially any of those listed above.
-
- WARNINGS
-
- * Tell your doctor about unusual or allergic reactions you have had to
- any medications, especially to phenmetrazine or other appetite suppressants
- (such as benzphetamine, phendimetrazine, diethylpropion, fenfluramine,
- mazindol, and phentermine), or to epinephrine, norepinephrine, ephedrine,
- amphetamines, dextroamphetamine, phenylephrine, phenylpropanolamine,
- pseudoephedrine, albuterol, metaproterenol, or terbutaline.
- * Tell your doctor if you have a history of drug abuse or if you now have
- or have ever had angina, diabetes mellitus, emotional disturbances, glaucoma,
- heart or cardiovascular disease, high blood pressure, or thyroid disease.
- * Phenmetrazine can mask the symptoms of extreme fatigue and can cause
- dizziness or light-headedness. Your ability to perform tasks that require
- alertness, such as driving a car or operating potentially dangerous machinery,
- may be decreased. Appropriate caution should, therefore, be taken.
- * Before having surgery or any other medical or dental treatment, be sure
- to tell your doctor or dentist that you are taking this medication.
- * Phenmetrazine is related to amphetamine and may be habit-forming when
- taken for long periods of time (both physical and psychological dependence can
- occur). Therefore, you should not increase your dosage of this medication or
- take it for longer than 12 weeks, unless you first consult your doctor. It is
- also important that you not stop taking this medication abruptly--fatigue,
- sleep disorders, mental depression, nausea or vomiting, or stomach cramps or
- pain could occur. Your doctor may, therefore, want to decrease the dosage
- gradually in order to prevent or minimize these side effects.
- * Phenmetrazine 75-mg sustained-release tablets contain the color
- additive FD&C Yellow No. 5 (tartrazine), which can cause allergic-type
- reactions (fainting, shortness of breath, or rash) in certain susceptible
- individuals.
- * Be sure to tell your doctor if you are pregnant. Although studies of
- phenmetrazine in humans have not been conducted, some of the appetite
- suppressants have been shown to cause side effects in the fetuses of animals
- that received large doses during pregnancy. Also, tell your doctor if you are
- breast-feeding an infant. It is not known whether this medication passes into
- breast milk.
-
- ----------------
-
- The material contained here is "FOR INFORMATION ONLY" and should not replace
- the counsel and advice of your personal physician. Promptly consulting your
- doctor is the best path to a quick and successful resolution of any medical
- problem.
-